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1-Azakenpaullone
CAS No. 676596-65-9
1-Azakenpaullone( 1-Azakenpaullone )
Catalog No. M15585 CAS No. 676596-65-9
1-Azakenpaullone is an analog of kenpaullone and is a potent, selective GSK3β inhibitor with IC50 of 18 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 91 | In Stock |
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| 5MG | 178 | In Stock |
|
| 10MG | 295 | In Stock |
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| 25MG | 531 | In Stock |
|
| 50MG | 759 | In Stock |
|
| 100MG | 1035 | In Stock |
|
| 500MG | 2061 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name1-Azakenpaullone
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NoteResearch use only, not for human use.
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Brief Description1-Azakenpaullone is an analog of kenpaullone and is a potent, selective GSK3β inhibitor with IC50 of 18 nM.
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Description1-Azakenpaullone is an analog of kenpaullone and is a potent, selective GSK3β inhibitor with IC50 of 18 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=2.0 and 4.2 uM); stimulates the proliferation of human pancreatic islets and drives the differentiation of mouse embryonic stem cells.
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In VitroReal Time qPCR Cell Line:human MSCs Concentration:3 μM Incubation Time:48 hResult:Increased gene expression of osteoblast-specific marker genes (ALP, OC, ON, COL1A1, and OPN).
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In Vivo——
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Synonyms1-Azakenpaullone
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PathwayPI3K/Akt/mTOR signaling
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TargetGSK-3
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RecptorGSK-3β
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number676596-65-9
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Formula Weight328.169
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Molecular FormulaC15H10BrN3O
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Purity>98% (HPLC)
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SolubilityDMSO: 61 mg/mL (185.9 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C(NC1=CC=CN=C12)CC3=C2NC4=C3C=C(Br)C=C4
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Chemical Name9-bromo-7,12-dihydro-pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kunick C, et al. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.
2. Mishra R, et al. J Biol Chem. 2007 Oct 19;282(42):30393-405.
3. Mfopou JK, et al. Stem Cell Res. 2014 Jan;12(1):166-77.
4. Liu H, et al. Diabetes. 2009 Mar;58(3):663-72.
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