yangonin

Research use only, not for human use.

Yangonin is a novel CB? receptor ligand, it exhibits affinity for the human recombinant CB? receptor.

Yangonin is a novel CB? receptor ligand, it exhibits affinity for the human recombinant CB? receptor. Yangonin could be a valuable candidate for the intervention of NF-κB-dependent pathological conditions such as inflammation.(In Vitro):Yangonin is one of the six major kavalactones found in Piper methysticum.Yangonin potently inhibits NF-κB activation through suppression of the transcriptional activity of the RelA/p65 subunit of NF-κB. Yangonin significantly inhibits the induced expression of the NF-κB-reporter gene. However, Yangonin does not interfere with TNF-α-induced inhibitor of κBα (IκBα) degradation, p65 nuclear translocation, and DNA-binding activity of NF-κB. Yangonin inhibits not only the induced NF-κB activation by overexpression of RelA/p65, but also transactivation activity of RelA/p65. Yangonin does not inhibit TNF-α-induced activation of p38, but it significantly impairs activation of ERK 1/2 and stress-activated protein kinase/JNK.

Yangonin is one of the six major kavalactones found in Piper methysticum.Yangonin potently inhibits NF-κB activation through suppression of the transcriptional activity of the RelA/p65 subunit of NF-κB. Yangonin significantly inhibits the induced expression of the NF-κB-reporter gene. However, Yangonin does not interfere with TNF-α-induced inhibitor of κBα (IκBα) degradation, p65 nuclear translocation, and DNA-binding activity of NF-κB. Yangonin inhibits not only the induced NF-κB activation by overexpression of RelA/p65, but also transactivation activity of RelA/p65. Yangonin does not inhibit TNF-α-induced activation of p38, but it significantly impairs activation of ERK 1/2 and stress-activated protein kinase/JNK.

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Endocrinology/Hormones

AChR

NF-κB

Inflammation/Immunology

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500-62-9

258.27

C15H14O4

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (96.80 mM)

COC1=CC=C(C=C1)C=CC2=CC(=CC(=O)O2)OC

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(-20℃)

With Ice Pack

≥ 2 years