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palovarotene

CAS No. 410528-02-8

palovarotene( RO-3300074 | RO 3300074 | RO3300074 | R-667 )

Catalog No. M17504 CAS No. 410528-02-8

Palovarotene is an agonist of nuclear retinoic acid receptor γ (RAR-γ).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    palovarotene
  • Note
    Research use only, not for human use.
  • Brief Description
    Palovarotene is an agonist of nuclear retinoic acid receptor γ (RAR-γ).
  • Description
    Palovarotene, also known as RO-3300074 and R-667, is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential treatment for emphysema. Phase I clinical trials of palovarotene in patients with emphysema demonstrated that the drug is well tolerated, with improvements observed in markers of emphysema progression. Emphysema is characterized by the destruction of alveoli and alveolar ducts within the lungs. Retinoid signaling is believed to play a role in alveologenesis, with the retinoic acid receptor gamma thought to be required for alveolar formation.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RO-3300074 | RO 3300074 | RO3300074 | R-667
  • Pathway
    Angiogenesis
  • Target
    c-Met/HGFR
  • Recptor
    RARγ
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    410528-02-8
  • Formula Weight
    414.55
  • Molecular Formula
    C27H30N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 19.5 mg/mL. 47.04 mM;
  • SMILES
    O=C(O)c1ccc(cc1)/C=C/c3cc4c(cc3Cn2cccn2)C(C)(C)CCC4(C)C
  • Chemical Name
    4-((1E)-2-(5,5,8,8-Tetramethyl-3-(1H-pyrazol-1-ylmethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl)benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pavey GJ, et al. Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model. Bone. 2016 Sep;90:159-67.
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