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dCeMM2

CAS No. 296771-07-8

dCeMM2( —— )

Catalog No. M35561 CAS No. 296771-07-8

dCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 68 In Stock
10MG 116 In Stock
25MG 242 In Stock
50MG 413 In Stock
100MG 600 In Stock
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Biological Information

  • Product Name
    dCeMM2
  • Note
    Research use only, not for human use.
  • Brief Description
    dCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K.
  • Description
    dCeMM2 (Compound 2) is a glue degrader. dCeMM2 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Molecular Glues
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    296771-07-8
  • Formula Weight
    370.82
  • Molecular Formula
    C16H11ClN6OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 41.67 mg/mL (112.37 mM; Ultrasonic (<60°C)
  • SMILES
    Clc1ccc(NC(=O)CSc2nnc3c(n2)[nH]c2ccccc32)nc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling [published correction appears in Nat Chem Biol. 2021 Mar;17(3):361]. Nat Chem Biol. 2020;16(11):1199-1207.?
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