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Zaurategrast

CAS No. 455264-31-0

Zaurategrast( CDP-323 | CDP 323 | CDP323 )

Catalog No. M14541 CAS No. 455264-31-0

A potent and selective, orally bioavailable α4 integrin (α4β1/VLA-4 and, to a lesser extent, α4β7 integrin) antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Zaurategrast
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective, orally bioavailable α4 integrin (α4β1/VLA-4 and, to a lesser extent, α4β7 integrin) antagonist.
  • Description
    A potent and selective, orally bioavailable α4 integrin (α4β1/VLA-4 and, to a lesser extent, α4β7 integrin) antagonist, an ester prodrug of CT-7758; is developed for the treatment of multiple sclerosis.Multiple Sclerosis Phase 2 Discontinued.
  • In Vitro
    Zaurategrast (CT7758) is a carboxylate containing α4β1/α4/β7 integrin antagonist.
  • In Vivo
    ——
  • Synonyms
    CDP-323 | CDP 323 | CDP323
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Integrin
  • Recptor
    Integrin
  • Research Area
    Inflammation/Immunology
  • Indication
    Multiple Sclerosis

Chemical Information

  • CAS Number
    455264-31-0
  • Formula Weight
    521.4057
  • Molecular Formula
    C26H25BrN4O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(O)[C@@H](NC1=C(Br)C(C12CCCCC2)=O)CC3=CC=C(NC4=NC=CC5=C4C=NC=C5)C=C3
  • Chemical Name
    L-Phenylalanine, N-(2-bromo-3-oxospiro[3.5]non-1-en-1-yl)-4-(2,7-naphthyridin-1-ylamino)- (9CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bailey, et al. Current Immunology Reviews, 2012, 8, 135-1402. Wolf C, et al. PLoS One. 2013;8(3):e58438. 3. Chanteux H, et al. Drug Metab Dispos. 2014 Jan;42(1):153-61.
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