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YM-155
CAS No. 781661-94-7
YM-155( YM155 | Sepantronium bromide | YM 155 )
Catalog No. M15948 CAS No. 781661-94-7
A potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 30 | In Stock |
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| 5MG | 45 | In Stock |
|
| 10MG | 65 | In Stock |
|
| 25MG | 136 | In Stock |
|
| 50MG | 243 | In Stock |
|
| 100MG | 397 | In Stock |
|
| 500MG | 882 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameYM-155
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM.
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DescriptionA potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM; does not significantly inhibit SV40 promoter activity (>30 uM); suppresses expression of survivin and induces apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nM, without effect on IAP- or Bcl-2-related proteins; induces massive tumor regression in PC-3 tumor mice model (3-10 mg/kg).Blood Cancer Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsYM155 | Sepantronium bromide | YM 155
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PathwayApoptosis
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TargetIAP
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RecptorSurvivin
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number781661-94-7
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Formula Weight443.2939
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Molecular FormulaC20H19BrN4O3
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Purity>98% (HPLC)
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SolubilityDMSO: 10.66 mg/mL
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SMILESO=C(C1=C2[N+](CCOC)=C(C)N1CC3=NC=CN=C3)C4=C(C=CC=C4)C2=O.[Br-]
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Chemical Name1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-, bromide (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nakahara T, et al. Cancer Res. 2007 Sep 1;67(17):8014-21.
2. Iwasa T, et al. Clin Cancer Res. 2008 Oct 15;14(20):6496-504.
3. Satoh T, et al. Clin Cancer Res. 2009 Jun 1;15(11):3872-80.
4. Iwasa T, et al. Br J Cancer. 2010 Jun 29;103(1):36-42.
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