WF-210( WF210 )

Catalog No. M10980 CAS No. 1242279-00-0

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Datasheet

HNMR

HPLC

MSDS

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Product Name

WF-210
Note

Research use only, not for human use.
Brief Description

WF-210 is a PAC-1 derivative and potent activator of procaspases-3 with EC50 of 0.95 uM.
Description

WF-210 is a PAC-1 derivative and potent activator of procaspases-3 with EC50 of 0.95 uM, displays more cytotoxic than PAC‐1 to human cancer cells, but less cytotoxic to normal cells; exhibits an enhanced zinc chelating ability (EC50=2.88 uM) compared to PAC‐1, activates procaspase-3 through relief of zinc-mediated inhibition; more potently induces cancer cell death in vitro with mean IC50 of 0.88 uM against 15 cancer cell lines, induces apoptosis in HL-60 and U-937 cells via a caspase-dependent pathway, activates procaspase-3, reduces IAPs, and inhibits tumor growth in breast, liver, and gallbladder xenograft tumor models.
In Vitro

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In Vivo

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Synonyms

WF210
Pathway

Apoptosis
Target

Caspase
Recptor

Caspase
Research Area

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Indication

——

CAS Number

1242279-00-0
Formula Weight

791.855
Molecular Formula

C41H38FN7O7S
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(N/N=C/C1=CC=C(OCC2=CSC(CC3=CC=C(OCO4)C4=C3)=N2)C=C1O)CN5CCN(CC6=NC(C7=CC=C(COC8=CC=C(F)C=C8)C=C7)=NO6)CC5
Chemical Name

N'-(4-((2-(benzo[d][1,3]dioxol-5-ylmethyl)thiazol-4-yl)methoxy)-2-hydroxybenzylidene)-2-(4-((3-(4-((4-fluorophenoxy)methyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)piperazin-1-yl)acetohydrazide

1. Wang F, et al. Eur J Pharmacol. 2018 Feb 15;821:29-38. 2. Wang F, et al. Mol Oncol. 2014 Dec;8(8):1640-52.

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