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VA-K-14 hydrochloride
CAS No. 1171341-19-7
VA-K-14 hydrochloride( —— )
Catalog No. M34462 CAS No. 1171341-19-7
VA-K-14 hydrochloride（VAK14 HCl） is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogates TSHR signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 82 | Get Quote |
|
| 5MG | 121 | Get Quote |
|
| 10MG | 186 | Get Quote |
|
| 25MG | 364 | Get Quote |
|
| 50MG | 593 | Get Quote |
|
| 100MG | 888 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameVA-K-14 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionVA-K-14 hydrochloride（VAK14 HCl） is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogates TSHR signaling.
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DescriptionVA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC50= 12.3 μM).
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorTSH Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1171341-19-7
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Formula Weight341.86
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Molecular FormulaC18H16ClN3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (146.26 mM; Ultrasonic )
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SMILESCl.CNc1nc(cs1)-c1c([nH]c2ccccc12)-c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Latif R, et al. TSH Receptor Signaling Abrogation by a Novel Small Molecule. Front Endocrinol (Lausanne). 2016;7:130. Published 2016 Sep 27. ?
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