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UCN-01
CAS No. 112953-11-4
UCN-01( 7-Hydroxystaurosporine | NSC 638850 )
Catalog No. M10455 CAS No. 112953-11-4
UCN-01 (7-Hydroxystaurosporine;NSC 638850) is a synthetic derivative of staurosporine that has antiproliferative activity against several in vitro and in vivo cancer models.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameUCN-01
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NoteResearch use only, not for human use.
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Brief DescriptionUCN-01 (7-Hydroxystaurosporine;NSC 638850) is a synthetic derivative of staurosporine that has antiproliferative activity against several in vitro and in vivo cancer models.
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DescriptionUCN-01 (7-Hydroxystaurosporine;NSC 638850) is a synthetic derivative of staurosporine that has antiproliferative activity against several in vitro and in vivo cancer models; inhibits a variety of kinases, including Akt, PKC (IC50=30 nM), PDK1 (IC50=6 nM), CDKs (IC50=300-600 nM for Cdk1 and Cdk2); arrests tumor cells in the G1/S phase of the cell cycle and prevents nucleotide excision repair by Chk1 (IC50=7 nM); induces apoptosis.
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In Vitro——
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In Vivo——
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Synonyms7-Hydroxystaurosporine | NSC 638850
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PathwayAngiogenesis
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TargetPKC
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RecptorPKC
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Research Area——
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Indication——
Chemical Information
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CAS Number112953-11-4
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Formula Weight482.5
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Molecular FormulaC28H26N4O4
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C[C@@H](O)C=C12)C1=C3C4=CN=CC4=C5C6=C3N2C/C=C\[C@@](O7)(C)[C@@H](OC)[N@@]6(NC)C8=C5C=C[C@@]7([H])C8
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Chemical Name(3R,9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kawabe T. Mol Cancer Ther. 2004 Apr;3(4):513-9.
2. Peifer C, et al. ChemMedChem. 2008 Dec;3(12):1810-38.
3. Facchinetti MM, et al. Cancer Res. 2004 May 15;64(10):3629-37.
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