UC-112( UC112 )

Catalog No. M14330 CAS No. 383392-66-3

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Product Name

UC-112
Note

Research use only, not for human use.
Brief Description

UC-112 is a novel IAP inhibitor that potently inhibits human melanoma (A375 and M14) and human prostate (PC-3 and DU145) cancer cell lines with IC50 of 0.7-3.4 uM.
Description

UC-112 is a novel IAP inhibitor that potently inhibits human melanoma (A375 and M14) and human prostate (PC-3 and DU145) cancer cell lines with IC50 of 0.7-3.4 uM; also potently inhibits the growth of P-gp-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at 1 uM; strongly inhibits tumor growth and reduces both X chromosome-linked IAP and survivin levels in an A375 human melanoma xenograft model in vivo.
In Vitro

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In Vivo

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Synonyms

UC112
Pathway

Apoptosis
Target

IAP
Recptor

IAP
Research Area

Cancer
Indication

——

CAS Number

383392-66-3
Formula Weight

348.4382
Molecular Formula

C22H24N2O2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

OC1=C2N=CC=CC2=C(COCC3=CC=CC=C3)C=C1CN4CCCC4
Chemical Name

8-Quinolinol, 5-[(phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-

1. Wang J, et al. J Pharmacol Exp Ther. 2014 May;349(2):319-29. 2. Xiao M, et al. PLoS One. 2015 Jun 12;10(6):e0129807.

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