Tz-Thalidomide( —— )

Catalog No. M37130 CAS No. 2087490-42-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Tz-Thalidomide
Note

Research use only, not for human use.
Brief Description

Tz-Thalidomide is a tetrazine-modified Thalidomide (E3 ligase ligand) with some affinity for BRD4.
Description

Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2). Tz-Thalidomide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
In Vitro

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In Vivo

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Synonyms

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Pathway

Chromatin/Epigenetic
Target

Epigenetic Reader Domain
Recptor

Epigenetic Reader Domain
Research Area

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Indication

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CAS Number

2087490-42-2
Formula Weight

571.58
Molecular Formula

C29H29N7O6
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (87.48 mM; Ultrasonic )
SMILES

O=C1NC(=O)C(N2C(=O)C=3C=CC=C(OCCCCCC(=O)NCC=4C=CC(=CC4)C5=NN=C(N=N5)C)C3C2=O)CC1
Chemical Name

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1. Lebraud H, et al. Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras. ACS Cent Sci. 2016 Dec 28;2(12):927-934.?

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