Cart
sales@molnova.com
Tuvusertib
CAS No. 1613200-51-3
Tuvusertib( —— )
Catalog No. M32792 CAS No. 1613200-51-3
Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 μΜ) with selective and potentially antitumor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 103 | Get Quote |
|
| 5MG | 157 | Get Quote |
|
| 10MG | 244 | Get Quote |
|
| 25MG | 456 | Get Quote |
|
| 50MG | 637 | Get Quote |
|
| 100MG | 881 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameTuvusertib
-
NoteResearch use only, not for human use.
-
Brief DescriptionTuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 μΜ) with selective and potentially antitumor activity.
-
DescriptionTuvusertib (M1774; ATR inhibitor 1) is a selective and orally active ATR inhibitor extracted from patent WO2015187451A1, compound I-l, with a Ki value below 1 μΜ.
-
In VitroWestern Blot Analysis Cell Line:U266 and OPM2 cells Concentration:0-2 μM Incubation Time:24 h Result:Increased level of γH2A.X, cleavage of caspase-3, and cleavage of PARP.
-
In Vivo——
-
Synonyms——
-
PathwayAngiogenesis
-
TargetChk
-
RecptorChk | ATM/ATR | Apoptosis
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1613200-51-3
-
Formula Weight370.32
-
Molecular FormulaC16H12F2N8O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 5 mg/mL (13.50 mM; Ultrasonic )
-
SMILESCn1cncc1-c1c(F)cncc1NC(=O)c1c(N)nn2cc(F)cnc12
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Nadia AHMAD, et al. Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof. WO2015187451A1
molnova catalog
related products
-
AZD-7762
AZD-7762 (AZD7762) is a?potent and selective inhibitor of Chk1/2 with IC50 of 5 nM.
-
Baricitinib
Baricitinib (LY3009104, INCB028050) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM in cell-free assays.
-
LY2603618
A potent and selective small molecule inhibitor of Chk1 (IC50=?7 nM); promotes impaired DNA synthesis and elevates H2A.X phosphorylation indicative of DNA damage and premature entry into mitosis.
