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Troleandomycin

CAS No. 2751-09-9

Troleandomycin( —— )

Catalog No. M33708 CAS No. 2751-09-9

Troleandomycin (Triacetyloleandomycin), a macrolide antibiotic, is an orally active and specific CYP3A inhibitor that induces mnemonic speech, induces prolonged cholestasis, and can be used in the study of asthma.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Troleandomycin
  • Note
    Research use only, not for human use.
  • Brief Description
    Troleandomycin (Triacetyloleandomycin), a macrolide antibiotic, is an orally active and specific CYP3A inhibitor that induces mnemonic speech, induces prolonged cholestasis, and can be used in the study of asthma.
  • Description
    Troleandomycin (Triacetyloleandomycin), a macrolide acrolide antibiotic, is a selective CYP3A inhibitor. Troleandomycin is an oral corticosteroid for asthma study.
  • In Vitro
    ——
  • In Vivo
    Animal Model:SD female rats.Dosage:500 mg/kg.Administration:A single oral dose.Result:Markedly elevated the Cmax and AUC0-6 of simvastatin by 9.5- and 10.2-fold, respectively.
  • Synonyms
    ——
  • Pathway
    Microbiology/Virology
  • Target
    Antibiotic
  • Recptor
    Antibiotic | P450
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2751-09-9
  • Formula Weight
    813.97
  • Molecular Formula
    C41H67NO15
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 83.33 mg/mL (102.37 mM; Ultrasonic )
  • SMILES
    [H][C@@]1(C[C@H](OC)[C@@H](OC(C)=O)[C@H](C)O1)O[C@H]1[C@H](C)[C@@H](O[C@]2([H])O[C@H](C)C[C@@H]([C@H]2OC(C)=O)N(C)C)[C@@H](C)C[C@@]2(CO2)C(=O)[C@H](C)[C@@]([H])(OC(C)=O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]1C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shingen Misaka, et al. Green tea extract affects the cytochrome P450 3A activity and pharmacokinetics of simvastatin in rats. Drug Metab Pharmacokinet. 2013;28(6):514-8.?
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