Triparanol

Research use only, not for human use.

Triparanol interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling.

Triparanol interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparanol suppresses human tumor growth and is an antilipemic agent with high ophthalmic toxicity.(In Vitro):Triparanol is an effective cholesterol biosynthesis inhibitor blocking the 24-dehydrocholesterol reductase. Triparanol can block proliferation and induce apoptosis in multiple human cancer cells including lung, breast, liver, pancreatic, prostate cancer, and melanoma cells, and growth inhibition can be rescued by the exogenous addition of cholesterol.

Triparanol can block proliferation and induce apoptosis in multiple human cancer cells including lung, breast, liver, pancreatic, prostate cancer and melanoma cells, and growth inhibition can be rescued by exogenous addition of cholesterol.

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NSC 65345 | NSC-65345 | NSC65345

Apoptosis

Apoptosis

A2A/A1

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78-41-1

438.01

C27H32ClNO2

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (114.16 mM)

CCN(CC)CCOc1ccc(cc1)C(O)(Cc1ccc(Cl)cc1)c1ccc(C)cc1

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(-20℃)

With Ice Pack

≥ 2 years