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Tpl2-IN-34
CAS No. 915363-56-3
Tpl2-IN-34( Tpl2 inhibitor 34 | MAP3K8-IN-34 )
Catalog No. M16575 CAS No. 915363-56-3
A potent, selective Tpl2 (cot/MAP3K8) inhibitor with IC50 of 1.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 123 | Get Quote |
|
| 5MG | 204 | Get Quote |
|
| 10MG | 330 | Get Quote |
|
| 25MG | 681 | Get Quote |
|
| 50MG | 1197 | Get Quote |
|
| 100MG | 1971 | Get Quote |
|
| 500MG | 3942 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTpl2-IN-34
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective Tpl2 (cot/MAP3K8) inhibitor with IC50 of 1.6 nM.
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DescriptionA potent, selective Tpl2 (cot/MAP3K8) inhibitor with IC50 of 1.6 nM; dispalys 6875-fold selectivity over EGFR. P38, Src, CAMKII, MK2, PKA, and PKC (IC50>10 uM); inhibits LPS-induced TNF-α production in whole blood with IC50 of 0.3 uM; shows good efficacy in inhibiting TNF-alpha production in a LPS-stimulated rat inflammation model; orally active.
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In Vitro——
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In Vivo——
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SynonymsTpl2 inhibitor 34 | MAP3K8-IN-34
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PathwayMAPK/ERK Signaling
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TargetMEK
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RecptorMEK
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number915363-56-3
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Formula Weight539.4347
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Molecular FormulaC26H25Cl2FN8
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCCN1CCC(CC1)N2C=C(N=N2)CNC3=CC4=C(C(=CN=C4C(=C3)Cl)C#N)NC5=CC(=C(C=C5)F)Cl
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Chemical Name3-Quinolinecarbonitrile, 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wu J, et al. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3485-8.
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