Cart
sales@molnova.com
Tpl2-IN-34
CAS No. 915363-56-3
Tpl2-IN-34( Tpl2 inhibitor 34 | MAP3K8-IN-34 )
Catalog No. M16575 CAS No. 915363-56-3
A potent, selective Tpl2 (cot/MAP3K8) inhibitor with IC50 of 1.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 123 | Get Quote |
|
| 5MG | 204 | Get Quote |
|
| 10MG | 330 | Get Quote |
|
| 25MG | 681 | Get Quote |
|
| 50MG | 1197 | Get Quote |
|
| 100MG | 1971 | Get Quote |
|
| 500MG | 3942 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameTpl2-IN-34
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective Tpl2 (cot/MAP3K8) inhibitor with IC50 of 1.6 nM.
-
DescriptionA potent, selective Tpl2 (cot/MAP3K8) inhibitor with IC50 of 1.6 nM; dispalys 6875-fold selectivity over EGFR. P38, Src, CAMKII, MK2, PKA, and PKC (IC50>10 uM); inhibits LPS-induced TNF-α production in whole blood with IC50 of 0.3 uM; shows good efficacy in inhibiting TNF-alpha production in a LPS-stimulated rat inflammation model; orally active.
-
In Vitro——
-
In Vivo——
-
SynonymsTpl2 inhibitor 34 | MAP3K8-IN-34
-
PathwayMAPK/ERK Signaling
-
TargetMEK
-
RecptorMEK
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number915363-56-3
-
Formula Weight539.4347
-
Molecular FormulaC26H25Cl2FN8
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESCCN1CCC(CC1)N2C=C(N=N2)CNC3=CC4=C(C(=CN=C4C(=C3)Cl)C#N)NC5=CC(=C(C=C5)F)Cl
-
Chemical Name3-Quinolinecarbonitrile, 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Wu J, et al. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3485-8.
molnova catalog
related products
-
Hederacolchiside A1
Hederacolchiside A1 shows anti-leishmanial activity it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential.
-
MEK inhibitor
MEK inhibitor is a tyrosine kinase receptor and cell cycle protein/CDK complex inhibitor with antitumor activity and can be used to study tumor cell proliferation.
-
BIX02189
BIX02189 is a potent, selective inhibitor of MEK5 catalytic activity with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity (IC50=59 nM).
