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Tozadenant
CAS No. 870070-55-6
Tozadenant( SYN-115 | SYN115 | SYN 115 )
Catalog No. M16320 CAS No. 870070-55-6
A potent, selective adenosine 2A receptor (A2A/NR2B) antagonist with Ki of 11.5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | In Stock |
|
| 5MG | 80 | In Stock |
|
| 10MG | 132 | In Stock |
|
| 25MG | 248 | In Stock |
|
| 50MG | 430 | In Stock |
|
| 100MG | 620 | In Stock |
|
| 500MG | 1332 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTozadenant
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective adenosine 2A receptor (A2A/NR2B) antagonist with Ki of 11.5 nM.
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DescriptionA potent, selective adenosine 2A receptor (A2A/NR2B) antagonist with Ki of 11.5 nM.Parkinson's Disease Phase 3 Discontinued(In Vivo):18F-MNI-444 regional uptake is consistent with A2A receptor distribution in the brain. Selectivity is demonstrated by dose-dependent blocking by tozadenant (1.5, 10.5 mg/kg) and preladenant.
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In Vitro——
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In Vivo18F-MNI-444 regional uptake is consistent with A2A receptor distribution in the brain. Selectivity is demonstrated by dose-dependent blocking by tozadenant (1.5, 10.5 mg/kg) and preladenant.
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SynonymsSYN-115 | SYN115 | SYN 115
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PathwayGPCR/G Protein
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TargetAdenosine Receptor
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RecptorAdenosine Receptor
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Research AreaNeurological Disease
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IndicationParkinson Disease
Chemical Information
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CAS Number870070-55-6
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Formula Weight406.4991
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Molecular FormulaC19H26N4O4S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(N1CCC(C)(O)CC1)NC2=NC3=C(OC)C=CC(N4CCOCC4)=C3S2
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Chemical Name1-Piperidinecarboxamide, 4-hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Barret O, et al. J Nucl Med. 2014 Oct;55(10):1712-8.
2. Black KJ, et al. J Neurosci. 2010 Dec 1;30(48):16284-92.
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