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Tovinontrine

CAS No. 2062661-53-2

Tovinontrine( —— )

Catalog No. M35598 CAS No. 2062661-53-2

Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tovinontrine
  • Note
    Research use only, not for human use.
  • Brief Description
    Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.
  • Description
    Tovinontrine (IMR-687) is a highly potent and selective phosphodiesterase-9 (PDE9) inhibitor specifically for the treatment of sickle cell disease. IC50s are 8.19 nM and 9.99 nM for PDE9A1 and PDE9A2, respectively.
  • In Vitro
    ——
  • In Vivo
    Animal Model:HbSS-Townes mice on a 129/B6 background (10-12 weeks old) Dosage:30 mg/kg Administration:Dosed daily by gavage for 30 days Result:Resulted in fetal hemoglobin (HbF) induction, reduced hemolysis and reduced reticulocytosis.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2062661-53-2
  • Formula Weight
    394.47
  • Molecular Formula
    C21H26N6O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (253.50 mM; Ultrasonic )
  • SMILES
    C[C@@H]1CN(Cc2ncccn2)C[C@H]1c1cn2c(ncc2c(=O)[nH]1)C1CCOCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. James G McArthur, et al.A novel, highly potent and selective phosphodiesterase-9 inhibitor for the treatment of sickle cell disease. Haematologica. 2020 Mar;105(3):623-631.?
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