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Tofimilast
CAS No. 185954-27-2
Tofimilast( CP-325366 )
Catalog No. M12872 CAS No. 185954-27-2
Tofimilast (CP-325366) is a potent, selective PDE4 inhibitor with IC50 of 23, 13 and 13 nM for PDE4A, PDE4B, and PDE4D, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 315 | Get Quote |
|
| 10MG | 477 | Get Quote |
|
| 25MG | 773 | Get Quote |
|
| 50MG | 1062 | Get Quote |
|
| 100MG | 1431 | Get Quote |
|
| 500MG | 2871 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTofimilast
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NoteResearch use only, not for human use.
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Brief DescriptionTofimilast (CP-325366) is a potent, selective PDE4 inhibitor with IC50 of 23, 13 and 13 nM for PDE4A, PDE4B, and PDE4D, respectively.
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DescriptionTofimilast (CP-325366) is a potent, selective PDE4 inhibitor with IC50 of 23, 13 and 13 nM for PDE4A, PDE4B, and PDE4D, respectively; shows weakly or no inhibition for PDE4C, and no activity for PDE1, PDE2, PDE3, PDE5, PDE6, and PDE7; increases cAMP levels in PGE1-stimulated U937 cells with an EC50 of 230 nM, inhibits human monocyte PDE mediated cAMP catabolism with an IC50 of 67 nM and LPS stimulated human monocyte TNFα release with an IC50 of 59 nM; shows low oral bioavailability and no emesis-associated behaviors in the ferret emesis model.Asthma Discontinued
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In Vitro——
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In Vivo——
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SynonymsCP-325366
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research AreaInflammation/Immunology
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IndicationAsthma
Chemical Information
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CAS Number185954-27-2
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Formula Weight339.461
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Molecular FormulaC18H21N5S
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Purity>98% (HPLC)
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Solubility——
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SMILESCCC1=NN(C2CCCC2)C3=C1CCN4C3=NN=C4C5=CC=CS5
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Chemical Name9-Cyclopentyl-7-ethyl-3-(thiophen-2-yl)-6,9-dihydro-5H-pyrazolo(3,4-c)-1,2,4-triazolo(4,3-a)pyridine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Duplantier AJ, et al. J Med Chem. 2007 Jan 25;50(2):344-9.
2. Giembycz MA. Br J Pharmacol. 2008 Oct;155(3):288-90.
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