Tobramycin

Research use only, not for human use.

Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius.

Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius.

Cell Viability Assay Cell Line:Pseudomonas aeruginosa Concentration:2,10,50 ng/mL Incubation Time:24 h Result:Greatly decreased cell viability compared to no protein or inactive mycobacterium fortuitum enzyme (PodA) controls while PodA10 alone did not increase cell death.

Animal Model:Murine Model of Pseudomonas aeruginosa Pneumonia Female, Swiss-Webster mice Dosage:50, 100, 150, 214, and 400 mg/kg/dayAdministration:Intraperitoneal injection (i.p.) ,once every 4hResult:Had near-maximal killing of the wild-type bacteria occurred at approximately 150 mg/kg/day when tobramycin alone. Combinated with Meropenem (HY-13678) produced near-maximal effect (i.e., bacterial cell kill) at low doses of both drugs (60 and 50 mg/kg/day for Meropenem (HY-13678) and tobramycin, respectively). Animal Model:Mice, rats, cats and dogs for toxicologic evaluationDosage:7.5,15,30,120,441,969 mg/kg Administration:Subcutaneous injection (s.c.), Intravenous injection (i.v.) ,Intramuscular injection(i.m.) Result:The s.c. LD50 values in mice and rats were 441 and 969 mg/kg, respectively. Within 1 hour after treated, death with central nervous system depression as a precursor occurred in rats and mice. A 100 mg/kg iv dose in chloraloseanesthetized catsproduced a moderate, transient decreasein blood pressure and a significant decrease in inspiratory volume and soleus twitch force. Changed renal tissue in rats which were given daily sc doses of 15-120 mg/kg for 3 months. im dose of 7.5 mg/kg for a l-month had no apparent effect on dogs, but a 30 mg/kg dose for a l-month produced severerenal damage.

Deoxykanamycin B | Distobram | Gernebcin | NSC 180514

Microbiology/Virology

ribosome

30S ribosome

Infection

——

32986-56-4

467.51

C18H37N5O9

>98% (HPLC)

Water: 94 mg/mL (201.05 mM)

O[C@H]1[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](CN)[C@@H](O)C[C@H]3N)[C@@H](N)C[C@H]2N)O[C@H](CO)[C@@H](O)[C@@H]1N

(2S,3R,4S,5S,6R)-4-Amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol

(-20℃)

With Ice Pack

≥ 2 years