Ticlopidine

Research use only, not for human use.

Ticlopidine is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.

Ticlopidine is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.(In Vitro):Ticlopidine exhibits activity against human CD39 with apparent Ki,app values of 14 μM.Ticlopidine inhibits recombinant human CD39 expressed in COS-7-cells with the Ki value of 127±12?μM.Growth rate is affected during the first days of culture, Ticlopidine (30 and 150 μM) reducing its effect in the following days.(In Vivo):Oral administration of Losartan with 10 mg/kg Ticlopidine significantly increases the AUC (by 65.0%), suggesting that Ticlopidine can effectively inhibit the metabolism of losartan in the intestine and/or liver.

Ticlopidine exhibits activity against human CD39 with apparent Ki,app values of 14 μM.Ticlopidine inhibits recombinant human CD39 expressed in COS-7-cells with the Ki value of 127±12?μM.Growth rate is affected during the first days of culture, Ticlopidine (30 and 150 μM) reducing its effect in the following days. Cell Proliferation Assay Cell Line:Human endothelial cells Concentration:30 and 150 μM Incubation Time:2, 6; 10 days Result:Treated cells grow slower if compared with controls and this effect correlates with the concentration of Ticlopidine in the culture medium.

Oral administration of Losartan with 10 mg/kg Ticlopidine significantly increases the AUC (by 65.0%), suggesting that Ticlopidine can effectively inhibit the metabolism of losartan in the intestine and/or liver. Animal Model:Male Sprague-Dawley rats (7-8 weeks old, weighing 270-300 g)Dosage:4 or 10 mg/kg Administration:Orally administered 30 min before oral administration of losartan.Result:The AUC and Cmax of Losartan after oral administration with Losartan and 10 mg/kg Ticlopidine were significantly greater (by 65.0% and 49.4%, respectively) than those of control rats.

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Angiogenesis

EGFR

ADP

Others-Field

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55142-85-3

263.78

C14H14ClNS

>98% (HPLC)

In Vitro:?DMSO : ≥ 100 mg/mL (379.09 mM)

C1CN(Cc2c1scc2)Cc1ccccc1Cl

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(-20℃)

With Ice Pack

≥ 2 years