Thiocolchicine

Research use only, not for human use.

Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 μM and a Ki of 0.7 μM. Thiocolchicine induces cell apoptosis.

Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 μM and a Ki of 0.7 μM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.(In Vitro):Thiocolchicine (1 nM-100 μM; 24-72 hours) shows a relationship between cell cycle blocking activity and growth inhibition in breast cancer cells. Thiocolchicine inhibits cell proliferation of MDA-MB-231 and multidrug-resistant (MDR) MCF-7 ADRr breast cancer cells with IC50s of 0.6 nM and 400 nM, respectively, as well as MDR CEM-VBL leukemia cells with an IC50 of 50 nM. Thiocolchicine is against MCF-7, LoVo, LoVo/DX, A-549 and BALB/3T3 cells with IC50 values of 0.01 μM, 0.021 μM, 0.398 μM, 0.011 μM and 0.114 μM, respectively.

Thiocolchicine is against MCF-7, LoVo, LoVo/DX, A-549 and BALB/3T3 cells with IC50 values of 0.01 μM, 0.021 μM, 0.398 μM, 0.011 μM and 0.114 μM, respectively.Thiocolchicine (1 nM-100 μM; 24-72 hours) shows a relationship between cell cycle blocking activity and growth inhibition in breast cancer cells. It inhibits cell proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells with IC50s of 0.6 nM and 400 nM, respectively, as well as MDR CEM-VBL leukemia cells (IC50=50 nM).

——

——

Cytoskeleton/Cell Adhesion Molecules

Microtubule/Tubulin

——

——

——

2730-71-4

415.5

C22H25NO5S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (240.67 mM)

COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(SC)ccc3-c2c(OC)c1OC

——

(-20℃)

With Ice Pack

≥ 2 years