ThioLox

Research use only, not for human use.

ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with an IC50 value of 12 μM, demonstrating significant anti-inflammatory and neuroprotective properties, including strong protection against glutamate toxicity.

ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with a Ki of 3.30 μM. ThioLox shows anti-inflammatory and neuroprotective properties.

RT-PCRCell Line:Precision-cut lung slices (PCLS) Concentration:1, 5, 10, 25 and 50 μM Incubation Time:In combination with 10 μM linoleic acid for 20 h and stimulated with 10 ng/mL LPS for the last 4 h.Result:Provided almost 50% inhibition of the expression of the pro-inflammatory genes IL-1β, IL-6, IL-8, IL-12b, TNFα and iNOS at 50 μM.Cell Viability Assay Cell Line:Neuronal HT-22 cells Concentration:5, 10 and 20 μMIncubation Time:14-16 h Result:Significantly reduced neuronal cell death against glutamate toxicity.

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Immunology/Inflammation

Lipoxygenase

Lipoxygenase

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1202193-89-2

274.38

C15H18N2OS

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (364.46 mM; Ultrasonic (<60°C)

C(NCCCC)(=O)C=1C=C(SC1N)C2=CC=CC=C2

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(-20℃)

With Ice Pack

≥ 2 years