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Tafetinib
CAS No. 1032265-57-8
Tafetinib( —— )
Catalog No. M34438 CAS No. 1032265-57-8
Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 380 | Get Quote |
|
| 5MG | 592 | Get Quote |
|
| 10MG | 843 | Get Quote |
|
| 25MG | 1224 | Get Quote |
|
| 50MG | 1638 | Get Quote |
|
| 100MG | 2187 | Get Quote |
|
| 500MG | 4392 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTafetinib
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NoteResearch use only, not for human use.
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Brief DescriptionTafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.
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DescriptionTafetinib (SIM010603) is an oral multi-targets receptor tyrosine kinases inhibitor. Tafetinib inhibitsstem cell factor receptor (Kit),vascular endothelial growth factor receptor-2 (VEGFR-2),platelet-derived growth factor receptor-β (PDGFR-β),glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), andFms-like tyrosine kinase-3 (FLT3)withIC50values between 5.0 and 68.1 nmol/l. Tafetinib inhibits the phosphorylation ofPDGFR-βandVEGFR-2. Tafetinib inhibits endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetTyrosinase
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RecptorTyrosine Kinases
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Research Area——
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Indication——
Chemical Information
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CAS Number1032265-57-8
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Formula Weight424.51
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Molecular FormulaC24H29FN4O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1/C(=C/2\C3=C(C(C(NCCN(CC)CC)=O)=C(C)N3)CCC2)/C=4C(N1)=CC=C(F)C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang D, et al. Preclinical anti-angiogenesis and anti-tumor activity of SIM010603, an oral, multi-targets receptor tyrosine kinases inhibitor. Cancer Chemother Pharmacol. 2012;69(1):173-183.?
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