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TNIK-IN-5
CAS No. 2754265-66-0
TNIK-IN-5( —— )
Catalog No. M28917 CAS No. 2754265-66-0
TNIK-IN-5 is an inhibitor of TNIK and can be used in studies about the treatment of anti-tumor and anti-inflammatory diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 393 | Get Quote |
|
| 10MG | 581 | Get Quote |
|
| 25MG | 888 | Get Quote |
|
| 50MG | 1242 | Get Quote |
|
| 100MG | 1674 | Get Quote |
|
| 500MG | 3348 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTNIK-IN-5
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NoteResearch use only, not for human use.
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Brief DescriptionTNIK-IN-5 is an inhibitor of TNIK and can be used in studies about the treatment of anti-tumor and anti-inflammatory diseases.
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DescriptionTNIK-IN-5 is an inhibitor of TNIK and can be used in studies about the treatment of anti-tumor and anti-inflammatory diseases.
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In VitroTNIK-IN-5 (compound 8g) (1.25-5 μM; 48 hours) significantly inhibits the cell proliferation of HCT116 in a dose-dependent manner.TNIK-IN-5 (1 μM; 24, 48 hours) strongly prevents HCT116 cells migration.TNIK-IN-5 (10-40 μM; 48 hours) concentration-dependently inhibits the protein levels of β-catenin and TCF-4 in the nucleus, and significantly decreases the expression of Wnt target gene products, including Axin2 and c-Myc.Cell Proliferation Assay Cell Line:HCT116?cells Concentration:1.25 μM, 2.5 μM, 5 μMIncubation Time:48 hours Result:Significantly inhibited the cell proliferation in a dose-dependent manner.
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In Vivo——
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Synonyms——
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PathwayWnt/Notch/Hedgehog
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TargetWnt/beta/catenin
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2754265-66-0
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Formula Weight371.39
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Molecular FormulaC22H17N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1OC=2C=C(C=CC2N1CC=3C=CC=C(OC)C3)C4=CN=C5NC=CC5=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tabefam M, et al. Antiprotozoal Diterpenes from Perovskia abrotanoides. Planta Med. 2018 Aug;84(12-13):913-919.
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