TGFβRI-IN-3( —— )

Catalog No. M37631 CAS No. 2763602-67-9

TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor with an IC50 of 0.79 nM and exhibits 2000-fold selectivity against MAP4K4, showing potential applications in immuno-oncology .

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
2MG	122	In Stock
5MG	187	In Stock
10MG	297	In Stock
25MG	564	In Stock
50MG	879	In Stock
100MG	1233	In Stock
500MG	2457	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

TGFβRI-IN-3
Note

Research use only, not for human use.
Brief Description

TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor with an IC50 of 0.79 nM and exhibits 2000-fold selectivity against MAP4K4, showing potential applications in immuno-oncology .
Description

TGFβRI-IN-3 inhibits TGFβR1 at an IC50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 represents a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

TGF-beta/Smad
Research Area

——
Indication

——

Chemical Information

CAS Number

2763602-67-9
Formula Weight

465.57
Molecular Formula

C28H23N3O2S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (107.40 mM; Ultrasonic (<60°C)
SMILES

N(C=1C2=C(C=C(C=C2)C3=CC=C(S(C)(=O)=O)C=C3)N=CC1)C=4C=C(N=CC4)C5=CC(C)=CC=C5
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Kharbanda A, et al. Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology [published online ahead of print, 2021 Aug 12]. Eur J Med Chem. 2021;225:113763.?

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