TC11

Research use only, not for human use.

TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.

TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.

TC11 (0~30 μM; 24 hours; KMS34 cells) induces cell death in KMS34.TC11 (5 μM; 0~48 hours; KMS34 cells) induces cell death occurs through an apoptotic pathway and downregulates MCL1 expression.TC11 (5 μM; 24 hours; KMS34 cells) induces M arrest. Cell Viability Assay Cell Line:KMS34 cells Concentration:0~30 μM Incubation Time:24 hours Result:Induced cell death.Western Blot Analysis Cell Line:KMS34 cells Concentration:5 μM Incubation Time:0~48 hours Result:Induced cell death occurs through an apoptotic pathway and downregulated MCL1 expression.Cell Cycle Analysis Cell Line:KMS34 cellsConcentration:5 μM Incubation Time:24 hours Result:Induced M arrest.

——

1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 | CLT-003

Apoptosis

Caspase

caspase-3|caspase-8|caspase-9

——

——

100823-03-8

322.4

C20H22N2O2

>98% (HPLC)

DMSO:10 mM

CC(C)C1=C(C(=CC=C1)C(C)C)N2C(=O)C3=C(C2=O)C=C(C=C3)N

——

(-20℃)

With Ice Pack

≥ 2 years