Cart
sales@molnova.com
TC-I 2014
CAS No. 1221349-53-6
TC-I 2014( —— )
Catalog No. M33511 CAS No. 1221349-53-6
TC-I 2014 shows antiallodynic properties in pain models.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 176 | In Stock |
|
| 5MG | 273 | In Stock |
|
| 10MG | 407 | In Stock |
|
| 25MG | 631 | In Stock |
|
| 50MG | 891 | In Stock |
|
| 100MG | 1152 | In Stock |
|
| 500MG | 2358 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTC-I 2014
-
NoteResearch use only, not for human use.
-
Brief DescriptionTC-I 2014 shows antiallodynic properties in pain models.
-
DescriptionTC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models.
-
In VitroTC-I 2014 (compound 5) potently inhibits cold-induced TRPM8 currents in HEK293 cells stably expressing canine or human TRPM8, with IC50 values of 0.413 and 1 nM, respectively.
-
In VivoTC-I 2014 (10 mg/kg, Orally once) completely prevents icilin-induced WDS.Animal Model:TC-I 2014 (10 mg/kg, Orally once) completely prevents icilin-induced WDS.Dosage:3, 5.6, 10 mg/kg.Administration:Orally once.Result:Produced greater than 90% inhibition at 3, 5.6, and 10 mg/kg administered 2 h prior to icilin challenge.
-
Synonyms——
-
PathwayMembrane Transporter/Ion Channel
-
TargetTRP/TRPV Channel
-
RecptorTRP/TRPV Channel
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1221349-53-6
-
Formula Weight467.41
-
Molecular FormulaC23H19F6N3O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 250 mg/mL (534.86 mM; Ultrasonic )
-
SMILESFC(F)(F)c1ccccc1-c1cc(c2[nH]c(nc2c1)C1=NOC2(C1)CCCCC2)C(F)(F)F
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Parks DJ, et Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J Med Chem. 2011 Jan 13;54(1):233-47.?
molnova catalog
related products
-
HC067047 Hydrochlori...
HC-067047 hydrochloride is a potent and selective TRPV4 antagonist.
-
BI-749327
BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).
-
A-967079
A potent, selective TRPA1 channel blocker with IC50 of 51 nM and 101 nM for hTRPA1 and rTRPA1, respectively.
