TBOPP

Research use only, not for human use.

TBOPP is a selective DOCK1 inhibitor (IC50 : 8.4 μM), with anti-tumor activity for broader types of tumors.

TBOPP is a selective DOCK1 inhibitor (IC50 : 8.4 μM), with anti-tumor activity for broader types of tumors. TBOPP as a selective inhibitor of DOCK1.?TBOPP dampened DOCK1-mediated invasion, macropinocytosis, and survival under the condition of glutamine deprivation without impairing the biological functions of the closely related DOCK2 and DOCK5 proteins.TBOPP treatment suppressed cancer metastasis and growth in vivo in mice.

Cell Viability Assay Cell Line:3LL cells Concentration:12.5 μM Incubation Time:3 days Result:Inhibited cell viability.

Animal Model:C57BL/6 mice (6- to 8-week-old) with ex-3LL cells Dosage:0.67 mg per mouse Administration:Administrated on days 0, 1, 3, and 5; for 2 weeks Result:The lung metastasis was significantly suppressed.

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Others

Other Targets

DOCK1|DOCK1 DHR-2 domain

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1996629-79-8

490.49

C24H21F3N2O4S

>98% (HPLC)

DMSO:120 mg/mL (244.65 mM; Need ultrasonic)

FC(F)(F)c1cccc(c1)-c1ccc(cc1)C(=O)Cn1cc(ccc1=O)S(=O)(=O)N1CCCC1

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(-20℃)

With Ice Pack

≥ 2 years