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TBAJ-587
CAS No. 2252316-16-6
TBAJ-587( —— )
Catalog No. M20563 CAS No. 2252316-16-6
TBAJ-587 is a potent anti-tuberculosis agent. TBAJ-587 inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 μg/mL in MABA and LORA assay respectively. BAJ-587 has more potent activity against M. tuberculosis and better efficacy in animal models of TB.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 260 | In Stock |
|
| 10MG | 407 | In Stock |
|
| 25MG | 671 | In Stock |
|
| 50MG | 945 | In Stock |
|
| 100MG | 1251 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTBAJ-587
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NoteResearch use only, not for human use.
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Brief DescriptionTBAJ-587 is a potent anti-tuberculosis agent. TBAJ-587 inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 μg/mL in MABA and LORA assay respectively. BAJ-587 has more potent activity against M. tuberculosis and better efficacy in animal models of TB.
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DescriptionTBAJ-587 is a potent anti-tuberculosis agent. TBAJ-587 inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 μg/mL in MABA and LORA assay respectively. BAJ-587 has more potent activity against M. tuberculosis and better efficacy in animal models of TB.
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In VitroBedaquiline is adrug of the diarylquinoline class that has proven to be clinically effective against drug-resistant tuberculosis, but has a cardiac liability due to its potent inhibition of the cardiac potassium channel protein hERG. TBAJ-587, an analogue of Bedaquiline, demonstrates more potent anti-tubercular activity, with greatly attenuated hERG blockade. TBAJ-587 inhibits hERG channel with an IC50 of 13 μM.
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In Vivo——
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Synonyms——
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PathwayMicrobiology/Virology
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TargetAntibiotic
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Recptortuberculosis
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Research Area——
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Indication——
Chemical Information
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CAS Number2252316-16-6
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Formula Weight614.5
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Molecular FormulaC30H33BrFN3O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 43.33 mg/mL (70.51 mM)
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SMILESCOc1cc(cc(OC)n1)C(O)(CCN(C)C)C(c1cccc(OC)c1F)c1cc2cc(Br)ccc2nc1OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sutherland H S Tong A S T Choi P J et al. 35-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel[J]. Bioorganic & Medicinal Chemistry 2019.
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