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TASK-1-IN-1
CAS No. 600125-11-9
TASK-1-IN-1( —— )
Catalog No. M36426 CAS No. 600125-11-9
TASK-1-IN-1 is a potent and selective inhibitor of TASK-1 (Potassium Channel) with an IC50 of 148 nM, and exhibits a reduced inhibitory effect on the TASK-3 channel with an IC50 of 1750 nM. TASK-1-IN-1 also demonstrates anticancer effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 52 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 122 | In Stock |
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| 25MG | 266 | In Stock |
|
| 50MG | 419 | In Stock |
|
| 100MG | 605 | In Stock |
|
| 500MG | 1287 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTASK-1-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionTASK-1-IN-1 is a potent and selective inhibitor of TASK-1 (Potassium Channel) with an IC50 of 148 nM, and exhibits a reduced inhibitory effect on the TASK-3 channel with an IC50 of 1750 nM. TASK-1-IN-1 also demonstrates anticancer effects.
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DescriptionTASK-1-IN-1 is a potent and selective TASK-1 (Potassium Channel) inhibitor with an IC50 of 148 nM. TASK-1-IN-1 shows a reduced inhibition of TASK-3 channels (IC50 of 1750 nM) and not a significant effect on other K+ channels. TASK-1-IN-1 has anticancer effects.
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In VitroTASK-1-IN-1 (compound F3) blocks cell proliferation and viability in the MCF-7 cancer cell line but not in TASK-1 knockdown MCF-7 cells, indicating that it is acting in TASK-1 channels.Cell Proliferation Assay Cell Line:MCF-7 cells Concentration:10 μM Incubation Time:96 hours Result:Showed an antiproliferative activity of ～45% on the cell line MCF-7.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number600125-11-9
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Formula Weight344.41
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Molecular FormulaC22H20N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 66.67 mg/mL (193.58 mM; Ultrasonic )
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SMILESN(C(=O)C1=CC(NC(=O)C2=CC=CC=C2)=CC=C1)C3=C(CC)C=CC=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bárbara Arévalo, et al. Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability. J Med Chem. 2022 Nov 24;65(22):15014-15027.?
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