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T247

CAS No. 1451042-18-4

T247( T 247 | HDAC3 inhibitor T247 )

Catalog No. M11944 CAS No. 1451042-18-4

A potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    T247
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8.
  • Description
    A potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8; induces dose-dependent selective increase of NF-κB acetylation in human colon cancer HCT116 cells, induces growth inhibition of cancer cells, and activates HIV gene expression in latent HIV-infected cells; shows promising activity for anticancer and antiviral benefits; also decreases TMEM16A expression and functional activity in both prostatic cancer cell line PC-3 and the breast cancer cell line YMB-1.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    T 247 | HDAC3 inhibitor T247
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1451042-18-4
  • Formula Weight
    389.477
  • Molecular Formula
    C21H19N5OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (64.19 mM)
  • SMILES
    O=C(NC1=CC=CC=C1N)C2=CC=C(C3=CN(CCC4=CSC=C4)N=N3)C=C2
  • Chemical Name
    N-(2-aminophenyl)-4-[1-(2-thiophen-3-ylethyl)-1H-[1],[2],[3]triazol-4-yl]benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Suzuki T, et al. PLoS One. 2013 Jul 16;8(7):e68669. 2. Matsuba S, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):510-8. 3. Methot JL, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):973-8.
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