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Succimer

CAS No. 304-55-2

Succimer( Succimer | DMSA )

Catalog No. M13963 CAS No. 304-55-2

Succimer is a Lead Chelator. The mechanism of action of succimer is as a Lead Chelating Activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Succimer
  • Note
    Research use only, not for human use.
  • Brief Description
    Succimer is a Lead Chelator. The mechanism of action of succimer is as a Lead Chelating Activity.
  • Description
    Succimer is a Lead Chelator. The mechanism of action of succimer is as a Lead Chelating Activity.(In Vivo):Succimer is a widely used chelating agent for the treatment of Pb poisoning. Red blood cells (RBCs) from lead exposed animals treated with NAC or Succimer are shown to have significantly higher glutathione (GSH) levels and diminished malondialdehyde (MDA) levels when compare to the lead group. Succimer administration also results in decreased glucose 6-phosphate dehydrogenase (G6PD) activity in RBCs from lead exposed animals. Succimer treatment produces a significant reduction in blood lead levels for both lead exposure conditions: the High Pb-succ group has blood lead levels that are 27% of the blood lead levels of the High Pb group at the end of treatment. Succimer is effective in substantially reducing brain lead, as brain lead levels in the High Pb-succ group are 37% of levels in the High Pb group.
  • In Vitro
    ——
  • In Vivo
    Succimer is a widely used chelating agent for the treatment of Pb poisoning. Red blood cells (RBCs) from lead exposed animals treated with NAC or Succimer are shown to have significantly higher glutathione (GSH) levels and diminished malondialdehyde (MDA) levels when compare to the lead group. Succimer administration also results in decreased glucose 6-phosphate dehydrogenase (G6PD) activity in RBCs from lead exposed animals. Succimer treatment produces a significant reduction in blood lead levels for both lead exposure conditions: the High Pb-succ group has blood lead levels that are 27% of the blood lead levels of the High Pb group at the end of treatment. Succimer is effective in substantially reducing brain lead, as brain lead levels in the High Pb-succ group are 37% of levels in the High Pb group.
  • Synonyms
    Succimer | DMSA
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Cadmium| Lead| Mercury| Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    304-55-2
  • Formula Weight
    182.22
  • Molecular Formula
    C4H6O4S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    O=C(O)[C@@H](S)[C@@H](S)C(O)=O
  • Chemical Name
    meso-2,3-Dimercaptosuccinic acid;

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Blanusa M, et al. Curr Med Chem. 2005;12(23):2771-94.
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