Cart
sales@molnova.com
Sotrastaurin
CAS No. 425637-18-9
Sotrastaurin( AEB071 | AEB 071 | AEB-071 )
Catalog No. M14447 CAS No. 425637-18-9
A potent, selective, orally available pan-PKC inhibitor with Ki of 0.22-3.2 nM for PKC isotypes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | In Stock |
|
| 10MG | 152 | In Stock |
|
| 25MG | 296 | In Stock |
|
| 50MG | 525 | In Stock |
|
| 100MG | 749 | In Stock |
|
| 500MG | 1494 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSotrastaurin
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective, orally available pan-PKC inhibitor with Ki of 0.22-3.2 nM for PKC isotypes.
-
DescriptionA potent, selective, orally available pan-PKC inhibitor with Ki of 0.22-3.2 nM for PKC isotypes; displays excellent selectivity against a broad panel of kinases (only GSK-3β IC50<1 uM); inhibits early T-cell activation with no general antiproliferative activity, also inhibits β2-integrin-mediated T-cell adhesiveness; prolongs rat heterotopic heart transplant survival in combination with adjunct immunosuppression agents.Blood Cancer Phase 2 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsAEB071 | AEB 071 | AEB-071
-
PathwayAngiogenesis
-
TargetPKC
-
RecptorPKCα|PKCβ1|PKCδ|PKCη|PKCθ
-
Research AreaCancer
-
IndicationBlood cancer
Chemical Information
-
CAS Number425637-18-9
-
Formula Weight438.4812
-
Molecular FormulaC25H22N6O2
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO=C(C(C1=CNC2=C1C=CC=C2)=C3C4=C5C=CC=CC5=NC(N6CCN(C)CC6)=N4)NC3=O
-
Chemical Name1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-[2-(4-methyl-1-piperazinyl)-4-quinazolinyl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Evenou JP, et al. J Pharmacol Exp Ther. 2009 Sep;330(3):792-801.
2. Wagner J, et al. J Med Chem. 2009 Oct 22;52(20):6193-6.
3. Budde K, et al. Am J Transplant. 2010 Mar;10(3):571-81.
molnova catalog
related products
-
PKCiota-IN-51
PKCiota-IN-51 is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.7 nM。
-
Protein Kinase C 19-...
Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.
-
Staurosporine
Staurosporine is a potent PKC inhibitor for PKCα, PKCγ and PKCη.
