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Soraprazan
CAS No. 261944-46-1
Soraprazan( —— )
Catalog No. M33128 CAS No. 261944-46-1
Soraprazan is a reversible, and fast-acting gastric H+/K+ ATPase inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 425 | Get Quote |
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| 25MG | 1408 | Get Quote |
|
| 50MG | 1831 | Get Quote |
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| 100MG | 2952 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSoraprazan
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NoteResearch use only, not for human use.
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Brief DescriptionSoraprazan is a reversible, and fast-acting gastric H+/K+ ATPase inhibitor.
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DescriptionSoraprazan (BYK61359) is a selective, reversible K-competitive inhibitor of the H,K-ATPase (Ki=6.4 nM), with an IC50 of 0.19 μM in gastric glands. Soraprazan binds to the H,K-ATPase with a Kd of 28.27 nM.Soraprazan shows immediate inhibition of acid secretion and is more than 2000-fold selective for H,K-ATPase over Na,K- and Ca-ATPases.
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In VitroSoraprazan (BYK61359) is a potent inhibitor of gastric H,K-ATPase, with an IC50 of 0.1 μM when measured in ion-leaky vesicles in the presence of 1 mM potassium. Soraprazan (BYK61359) also effectively inhibits dibutyryl cAMP-stimulated [14C]AP accumulation in isolated gastric glands with an IC50 of 0.19 μM (0.09-0.40 μM geometric mean from n=6 with 95% confidence limits).
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In VivoSoraprazan (1-27 μmol/kg; p.o.) shows rapid and consistent inhibition of acid secretion in dog .
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number261944-46-1
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Formula Weight367.44
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Molecular FormulaC21H25N3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 200 mg/mL (544.31 mM; Ultrasonic )
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SMILESCOCCO[C@H]1[C@H](O)[C@H](Nc2c1ccn1c(C)c(C)nc21)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Simon WA, et al. Soraprazan: setting new standards in inhibition of gastric acid secretion. J Pharmacol Exp Ther. 2007 Jun;321(3):866-74. Epub 2007 Mar 16.?
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