Somatostatin-25( —— )

Catalog No. M30508 CAS No. 76461-17-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Somatostatin-25
Note

Research use only, not for human use.
Brief Description

Somatostatin is an endogenous neuropeptide hormone found in the brain and pancreas. Somatostatin binds several isoforms of the somatostatin receptor, exhibiting anxiolytic, antiepileptic/anticonvulsant, and anorexigenic activities.
Description

Somatostatin is an endogenous neuropeptide hormone found in the brain and pancreas. Somatostatin binds several isoforms of the somatostatin receptor, exhibiting anxiolytic, antiepileptic/anticonvulsant, and anorexigenic activities. (In Vitro):Somatostatin-25 (0.1 pM-1 nM) significantly inhibits secretion of growth hormone in the in vitro system, and is 3-14 times more effective than the tetradecapeptide. Somatostatin-25 (0.1 nM-1pM) also inhibits secretion of growth hormone induced by the addition of prostaglandin 2 (PGE2). However, Somatostatin-25 shows no effect on the secretion of prolactin.
In Vitro

Somatostatin-25 (0.1 pM-1 nM) significantly inhibits secretion of growth hormone in the in vitro system, and is 3-14 times more effective than the tetradecapeptide. Somatostatin-25 (0.1 nM-1pM) also inhibits secretion of growth hormone induced by the addition of prostaglandin 2 (PGE2). However, Somatostatin-25 shows no effect on the secretion of prolactin.
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

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Research Area

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Indication

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CAS Number

76461-17-1
Formula Weight

2876.3
Molecular Formula

C127H191N37O34S3
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

Sequence:Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bridge: Cys14-Cys25)

Brazeau P, et al. High biological activity of the synthetic replicates of somatostatin-28 and somatostatin-25. Regul Pept. 1981 Jan;1(4):255-64.

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