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Smurf1-IN-A01

CAS No. 1007647-73-5

Smurf1-IN-A01( A01 )

Catalog No. M23212 CAS No. 1007647-73-5

Smurf1-IN-A01 is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (kd: 3.664 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Smurf1-IN-A01
  • Note
    Research use only, not for human use.
  • Brief Description
    Smurf1-IN-A01 is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (kd: 3.664 nM).
  • Description
    Smurf1-IN-A01 is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (kd: 3.664 nM). It increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation.
  • In Vitro
    ——
  • In Vivo
    Animal Model:retinal degeneration model mice Dosage:10 μM ,2μL Administration:Injected into vitreous cavity by micro-syringe Result:Reduced drusen-like spots.Resulted outer nuclear layers wider and straighter.Caused inner segment and outer segment hinge of photoreceptor cells disappeared.Down-regulated NLRP3 and inhibited IL-1β.
  • Synonyms
    A01
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Smurf1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1007647-73-5
  • Formula Weight
    512.93
  • Molecular Formula
    C22H20ClF3N4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:62.5 mg/mL (121.85 mM; Need ultrasonic)
  • SMILES
    CC1=CC=NN1C2=CC=C(C=C2)C(=O)N3CCN(CC3)S(=O)(=O)C4=CC(=C(C=C4)Cl)C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Cao Y, et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci Rep. 2014 May 14;4:4965.
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