Sirt2-PROTAC-1( Sirt2-PROTAC-1 | Sirt2 PROTAC-1 | Sirt2-PROTAC1 )

Catalog No. M13316 CAS No. 2098487-75-1

COA

Datasheet

HNMR

HPLC

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Product Name

Sirt2-PROTAC-1
Note

Research use only, not for human use.
Brief Description

A novel SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM).
Description

A novel SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM).
In Vitro

Western Blot Analysis Cell Line:HeLa cells Concentration:10 μM Incubation Time:1-6 hours Result:Caused Sirt2 degradation, but showed no effect on Sirt1 levels.
In Vivo

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Synonyms

Sirt2-PROTAC-1 | Sirt2 PROTAC-1 | Sirt2-PROTAC1
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

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Indication

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CAS Number

2098487-75-1
Formula Weight

852.942
Molecular Formula

C40H40N10O8S2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL 117.24 mM; H2O : < 0.1 mg/mL
SMILES

O=C(NC1=NC=C(CC2=CC=CC(OCC3=CN(CCCCNC(COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)N=N3)=C2)S1)CSC7=NC(C)=CC(C)=N7
Chemical Name

2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(3-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)thiazol-2-yl)acetamide

1. Schiedel M, et al. J Med Chem. 2017 Apr 17. doi: 10.1021/acs.jmedchem.6b01872.

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