Cart
sales@molnova.com
Selurampanel
CAS No. 912574-69-7
Selurampanel( BGG 492 )
Catalog No. M16551 CAS No. 912574-69-7
Selurampanel (BGG 492) is a selective, orally active and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.19 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 404 | Get Quote |
|
| 10MG | 581 | Get Quote |
|
| 25MG | 898 | Get Quote |
|
| 50MG | 1197 | Get Quote |
|
| 100MG | 1611 | Get Quote |
|
| 500MG | 3267 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameSelurampanel
-
NoteResearch use only, not for human use.
-
Brief DescriptionSelurampanel (BGG 492) is a selective, orally active and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.19 uM.
-
DescriptionSelurampanel (BGG 492) is a selective, orally active and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.19 uM; displays >100-fold selectivity over NMDA and kainate receptors; demonstrates excellent oral potency against MES-induced generalized tonic-clonic seizures in rodents as well as significant activity in patients suffering from various forms of epilepsy.Epilepsy Discontinued.
-
In Vitro——
-
In VivoSelurampanel (Compound 1S) potently and dose-dependently antagonizes maximal electroshock seizure (MES)-induced generalized tonic-clonic seizures in mice with an ED50 value around 7 mg/kg after 1 h pre-treatment.In a study with a 3 mg/kg i.v. dose, a mouse plasma half-life of 3.3 h is determined, with a moderate volume of distribution (Vdss=1.3 L/kg) and a low clearance of 5.4 mL/min?kg.
-
SynonymsBGG 492
-
PathwayMembrane Transporter/Ion Channel
-
TargetiGluR
-
RecptoriGluR
-
Research AreaNeurological Disease
-
IndicationEpilepsy
Chemical Information
-
CAS Number912574-69-7
-
Formula Weight377.418
-
Molecular FormulaC16H19N5O4S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCS(=O)(NN1C(NC2=C(C=C(C3=CC=NN3C)C(C(C)C)=C2)C1=O)=O)=O
-
Chemical NameN-(7-isopropyl-6-(1-methyl-1H-pyrazol-5-yl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)methanesulfonamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
S44819
S44819 (S-44819, Egis-1352 Afizagabar) is a novel potent, competitive, selective antagonist of the α5-GABAAR with Kd of 221 nM, IC50 of 585 nM (α5β2γ2).
-
Conantokin G
GluN2B (formally NR2B) selective, competitive antagonist of the NMDA receptor. Blocks NMDA-evoked current in mouse cortical neurons (IC50 = 480 nM); also inhibits NMDA-evoked responses in oocytes expressing GluN2B (formally NR2B), but not GluN2A (formally NR2A), subunits (IC50 ~300 nM). Exhibits neuroprotective properties in vivo and in vitro.
-
Org-26576
A potent AMPA receptor positive allosteric modulator; displays 10-30 fold greater potency in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 uM in rat hippocampal primary cultured neurons, compared to CX516.
