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Sabeluzole

CAS No. 104383-17-7

Sabeluzole( —— )

Catalog No. M34406 CAS No. 104383-17-7

Sabeluzole (R-58735) has antiepileptic and cognitive enhancing effects, inhibits neurotoxin-induced tau expression and cell death.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 97 Get Quote
5MG 145 Get Quote
10MG 216 Get Quote
25MG 352 Get Quote
50MG 518 Get Quote
100MG 707 Get Quote
500MG 1431 Get Quote
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Biological Information

  • Product Name
    Sabeluzole
  • Note
    Research use only, not for human use.
  • Brief Description
    Sabeluzole (R-58735) has antiepileptic and cognitive enhancing effects, inhibits neurotoxin-induced tau expression and cell death.
  • Description
    Sabeluzole (R 58735), a benzothiazol derivative, has antiischemic, antiepileptic, and cognitive-enhancing properties. Sabeluzole protects rat hippocampal neurons against NMDA- and glutamate-induced neurotoxicity via preventing tau expression. Sabeluzole enhances memory in rats, and prevents the amnesic effect of Chlordiazepoxide. Sabeluzole can be used fro research of Alzheimer's disease.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Adult albino male rats (270-330 g) induced by Chlordiazepoxide Dosage:5 mg/kg, 25 mg/kg Administration:SC; 0.5 ml/kg; twice dose with 72 h interval; 1 h before 20 mg/kg Chlordiazepoxide Result:Showed the positive effects on several learning and memory tasks in rats.Did not influence locomotor and rearing activity of animals during the acquisition session.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Microtubule Associated
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    104383-17-7
  • Formula Weight
    415.52
  • Molecular Formula
    C22H26FN3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    FC1=CC=C(OCC(O)CN2CCC(N(C3=NC=4C=CC=CC4S3)C)CC2)C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Uberti D, et al. Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death. Synapse. 1997 Jun;26(2):95-103. ?
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