SW-044248( SW 044248 | SW044248 )

Catalog No. M14846 CAS No. 522650-83-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SW-044248
Note

Research use only, not for human use.
Brief Description

SW-044248 is a novel selective inhibitor of Topoisomerase I; inhibits Top I differently from camptothecin.
Description

SW-044248 is a novel selective inhibitor of Topoisomerase I; inhibits Top I differently from camptothecin; selectively toxic for some NSCLC cell lines.Lung Cancer Preclinical.
In Vitro

SW044248 is a non-canonical Top1 inhibitor, and is selectively toxic for certain NSCLC cell lines. SW044248 shows no effect on Top2. SW044248 (2, 5, 10 μM) rapidly inhibits transcription, translation and DNA synthesis in sensitive cells (HCC4017 and H292 cells) but not insensitive cells (HBEC30KT cells and HCC44 cells). SW044248 (10 μM) rapidly activates the integrated stress response through kinases GCN2 and PKR. The inhibition of Top1 in HCC4017 cells is helpful to the toxicity of SW044248. SW044248 (5, 10 μM) shows no effect on HBEC30KT and HCC44 cell lines due to the up-regulation of p21CDKN1A. SW044248 is selectively toxic in 18/74 NSCLC lines.
In Vivo

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Synonyms

SW 044248 | SW044248
Pathway

Cell Cycle/DNA Damage
Target

Topoisomerase
Recptor

TopoI
Research Area

Cancer
Indication

Lung Cancer

CAS Number

522650-83-5
Formula Weight

421.5153
Molecular Formula

C22H23N5O2S
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 30 mg/mL
SMILES

CCN1C2=CC=CC=C2C3=C1N=C(N=N3)SC(C(NC4=CC=CC=C4OC)=O)CC
Chemical Name

Butanamide, 2-[(5-ethyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)thio]-N-(2-methoxyphenyl)-

1. Zubovych IO, et al. Mol Cancer Ther. 2016 Jan;15(1):23-36. 2. Kim HS, et al. Cell. 2013 Oct 24;155(3):552-66.

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