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SRX3177
CAS No. 2241237-51-2
SRX3177( —— )
Catalog No. M36306 CAS No. 2241237-51-2
SRX3177 is a novel and potent inhibitor of BRD4, PI3K and CDK.SRX3177 has potential anticancer activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 225 | Get Quote |
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| 5MG | 353 | Get Quote |
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| 10MG | 567 | Get Quote |
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| 25MG | 860 | Get Quote |
|
| 50MG | 1159 | Get Quote |
|
| 100MG | 1521 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSRX3177
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NoteResearch use only, not for human use.
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Brief DescriptionSRX3177 is a novel and potent inhibitor of BRD4, PI3K and CDK.SRX3177 has potential anticancer activity.
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DescriptionSRX3177 is a triple inhibitor of CDK4/6, PI3K, and BRD4, with IC50s of 33 nM (BRD4 BD1), 89 nM (BRD4 BD2), 79 nM (PI3Kα), 83 nM (PI3Kδ), 3.18 μM (PI3Kγ), <2.5 nM (CDK4), 3.3 nM (CDK6), respectively. SRX3177 exerts broad cytotoxic activity against cancer cells, but acts friendly with normal epithelial cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetEpigenetic Reader Domain
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RecptorEpigenetic Reader Domain | PI3K | CDK
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Research Area——
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Indication——
Chemical Information
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CAS Number2241237-51-2
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Formula Weight584.69
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Molecular FormulaC31H32N6O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (42.76 mM; Ultrasonic )
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SMILESC(N(C)C)(=O)C=1N(C=2C(C1)=CN=C(NC3=CC=C(C=C3)C=4C5=C(SC4)C(=O)C=C(O5)N6CCOCC6)N2)C7CCCC7
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Burgoyne AM, et al. A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity. Cell Discov. 2020 Jul 28;6(1):49.?
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