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SMO-IN-2

CAS No. 1822355-27-0

SMO-IN-2( —— )

Catalog No. M35720 CAS No. 1822355-27-0

SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medulloblastoma cell lines.SMO-IN-2 can be used in the study of cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SMO-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medulloblastoma cell lines.SMO-IN-2 can be used in the study of cancer.
  • Description
    SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway. SMO-IN-2 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity.
  • In Vitro
    SMO-IN-2 (compound 1) has antiproliferative activity against human medulloblastoma cell line Daoy with an IC50 of 0.51 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Hedgehog (Hh)
  • Recptor
    Hedgehog/Smoothened
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1822355-27-0
  • Formula Weight
    503.49
  • Molecular Formula
    C25H25F4N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N(C1=C(C(=O)N2CCC(N(C(=O)C3=C(C(F)(F)F)C=C(F)C=C3)C)CC2)C=CC=C1)C=4N(C)N=CC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ji D, et al. Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors. Bioorg Med Chem. 2020 Mar 15;28(6):115354.?
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