SM-1295( SM1295 )

Catalog No. M12227 CAS No. 1562375-46-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SM-1295
Note

Research use only, not for human use.
Brief Description

SM-1295 is a potent, selective cIAP1 and cIAP2 inhibitor with Ki of <10 nM, displays >900-fold for cIAP1 over XIAP.
Description

SM-1295 is a potent, selective cIAP1 and cIAP2 inhibitor with Ki of <10 nM, displays >900-fold for cIAP1 over XIAP; potently inhibits cell growth in the MDA-MB-231 and SK-OV-3 cancer cell lines and induces apoptosis at low nanomolar concentrations; efficiently induces degradation of cIAP1 protein in cancer cells, as well as cleavage of PARP, caspase-8, and caspase-3; induces cell death in a TNFα-dependent manner in both MDA-MB-231 and SK-OV-3 cancer cell lines.
In Vitro

SM-1295 (compound 5) binds to both cIAP1 and cIAP2 proteins with Ki values of <10 nM and displays a selectivity of >900-fold for cIAP1 over XIAP.SM-1295 (compound 5) exhibits an IC50 of 46 nM in MDA-MB-231.
In Vivo

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Synonyms

SM1295
Pathway

Apoptosis
Target

IAP
Recptor

IAP
Research Area

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Indication

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CAS Number

1562375-46-5
Formula Weight

598.542
Molecular Formula

C29H36BrN5O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 310 mg/mL (517.94 mM)
SMILES

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Chemical Name

Pyrrolo[1,2-a][1,5]diazocine-8-carboxamide, N-[(4-bromophenyl)methyl]decahydro-5-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-6-oxo-3-(2-phenylacetyl)-, (5S,8S,10aR)-

1. Sun H, et al. ACS Chem Biol. 2014 Apr 18;9(4):994-1002.

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