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SLC26A3-IN-2

CAS No. 950348-60-4

SLC26A3-IN-2( —— )

Catalog No. M36614 CAS No. 950348-60-4

SLC26A3-IN-2 is an orally active compound that functions as an inhibitor of the anion exchanger protein SLC26A3, with an IC50 of 360 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SLC26A3-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    SLC26A3-IN-2 is an orally active compound that functions as an inhibitor of the anion exchanger protein SLC26A3, with an IC50 of 360 nM.
  • Description
    SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC50=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    950348-60-4
  • Formula Weight
    368.84
  • Molecular Formula
    C19H13ClN2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 16.67 mg/mL (45.20 mM; Ultrasonic (<60°C)
  • SMILES
    O=C1N2C(=CSC2=NC(COC3=C(Cl)C=CC=C3)=C1)C4=CC=CC=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cil O, et al. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action. Eur J Med Chem. 2023 Mar 5;249:115149.?
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