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SIG1459
CAS No. 2234902-05-5
SIG1459( SIG-1459 | SIG 1459 )
Catalog No. M13582 CAS No. 2234902-05-5
SIG1459 (SIG-1459) is a novel anti-acne isoprenylcysteine (IPC) small molecule that shows direct antibacterial activity and inhibits TLR2 inflammatory signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSIG1459
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NoteResearch use only, not for human use.
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Brief DescriptionSIG1459 (SIG-1459) is a novel anti-acne isoprenylcysteine (IPC) small molecule that shows direct antibacterial activity and inhibits TLR2 inflammatory signaling.
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DescriptionSIG1459 (SIG-1459) is a novel anti-acne isoprenylcysteine (IPC) small molecule that shows direct antibacterial activity and inhibits TLR2 inflammatory signaling; shows antibacterial activity against C. acnes (MIC= 8.5 uM, MBC =16.1 uM, and MBEC= 12.5 uM), inhibits TLR2 induced IL-8 release from TLR2/TLR2 (IC50= 0.086 uM), TLR2/6 (IC50= 0.209 uM) and IL-1α from TLR2/TLR2 (IC50 =0.050 uM); demonstrates in vivo anti-acne activity.
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In Vitro——
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In Vivo——
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SynonymsSIG-1459 | SIG 1459
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number2234902-05-5
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Formula Weight584.768
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Molecular FormulaC29H50N2Na2O5S
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)CCCC(C)CCCC(C)CCCC(=CCSCC(C(=O)[O-])NC(=O)N1CCCC1C(=O)[O-])C.[Na+].[Na+]
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Chemical Name(((1R)-1-carboxy-2-(((E)-3,7,11,15-tetramethylhexadec-2-en-1-yl)thio)ethyl)carbamoyl)proline disodium salt
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fernández JR, et al. Exp Dermatol. 2018 Sep;27(9):993-999.
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