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SH-42

CAS No. 2143952-36-5

SH-42( —— )

Catalog No. M34858 CAS No. 2143952-36-5

SH-42 is a human Δ24-dehydrocholesterol reductase (DHCR24) inhibitor (IC50: 42 nM) that is selective and highly potent in inducing an increase in plasma desmethylferricinol levels.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SH-42
  • Note
    Research use only, not for human use.
  • Brief Description
    SH-42 is a human Δ24-dehydrocholesterol reductase (DHCR24) inhibitor (IC50: 42 nM) that is selective and highly potent in inducing an increase in plasma desmethylferricinol levels.
  • Description
    SH-42 is a potent and selective inhibitor of human Δ24-dehydrocholesterol reductase (DHCR24), with an IC50 of 42 nM. SH-42 can lead to a significant increase in plasma desmosterol levels of mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2143952-36-5
  • Formula Weight
    402.57
  • Molecular Formula
    C25H38O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 2 mg/mL (4.97 mM; Ultrasonic (<60°C)
  • SMILES
    C[C@@]12[C@@]3(C([C@]4([C@](C)(CC3)[C@@]([C@@H](COC=O)C)(CC4)[H])[H])=CC[C@]1(C[C@@H](OC(C)=O)CC2)[H])[H]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Müller C, et, al. New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. Eur J Med Chem. 2017 Nov 10;140:305-320.?
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