SGN-2FF

Research use only, not for human use.

SGN-2FF is an oral fucosyltransferase inhibitor with antitumor activity.

SGN-2FF is an oral fucosyltransferase inhibitor with antitumor activity.(In Vitro):SGN-2FF is a fucosylation inhibitor, SGN-2FF inhibits cellular fucosylation by depleting the fucosylation substrate GDP-fucose, and by direct inhibition of fucosyltransferases, and leads to the production of fucosylated glycoproteins including antibodies. SGN-2FF activates human T cells in an antigen-dependent manner.(In Vivo):In multiple mouse tumor models, SGN-2FF exhibits antitumor activity. SGN-2FF shows substantial tumor growth delay. SGN-2FF elevates the protective effect of a lymphoma vaccine in a syngeneic mouse model.

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Others

Other Targets

Telomerase

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2089647-47-0

166.148

C6H11FO4

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (300.93 mM)

C[C@@H]1OC(O)[C@@H](F)[C@H](O)[C@@H]1O

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(-20℃)

With Ice Pack

≥ 2 years