SGD-1882( PBD dimer | Pyrrolobenzodiazepine dimer )

Catalog No. M10845 CAS No. 1222490-34-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SGD-1882
Note

Research use only, not for human use.
Brief Description

SGD-1882 (PBD dimer, Pyrrolobenzodiazepine dimer) is a novel potent DNA-intercalating payload dimer (PBD dimer) payload for antibody-drug conjugates (ADCs).
Description

SGD-1882 (PBD dimer, Pyrrolobenzodiazepine dimer) is a novel potent DNA-intercalating payload dimer (PBD dimer) payload for antibody-drug conjugates (ADCs).
In Vitro

——
In Vivo

——
Synonyms

PBD dimer | Pyrrolobenzodiazepine dimer
Pathway

Antibody Drug Conjugates (ADC)
Target

ADC Cytotoxin
Recptor

ADC Cytotoxin
Research Area

Cancer
Indication

——

CAS Number

1222490-34-7
Formula Weight

725.802
Molecular Formula

C42H39N5O7
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (137.78 mM)
SMILES

COC1=CC=C(C=C1)C2=CN3C(C2)C=NC4=CC(=C(C=C4C3=O)OC)OCCCOC5=C(C=C6C(=C5)N=CC7CC(=CN7C6=O)C8=CC=C(C=C8)N)OC
Chemical Name

(S)-2-(4-aminophenyl)-7-methoxy-8-(3-(((S)-7-methoxy-2-(4-methoxyphenyl)-5-oxo-5,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl)oxy)propoxy)-1,11a-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one

1. Sean W. Smith, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00436

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