SCP1-IN-1( —— )

Catalog No. M35319 CAS No. 2764615-55-4

SCP1-IN-1 (compound SH T-62) is a potent and selective covalent inhibitor of SCP1, promoting REST degradation and reducing transcriptional activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

SCP1-IN-1
Note

Research use only, not for human use.
Brief Description

SCP1-IN-1 (compound SH T-62) is a potent and selective covalent inhibitor of SCP1, promoting REST degradation and reducing transcriptional activity.
Description

SCP1-IN-1 (compoundSH T-62) is a potent and selective covalent inhibitor against SCP1. SCP1-IN-1 promotes REST degradation and reduces transcriptional activity. A high level of REST protein drives the tumor growth in some glioblastoma cells. SCP1-IN-1 has the potential for the research of glioblastoma whose growth is driven by REST transcription activity.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

2764615-55-4
Formula Weight

520.5
Molecular Formula

C20H19F3N2O7S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (192.12 mM; Ultrasonic )
SMILES

FC(F)(F)Oc1ccc(cc1)S(=O)(=O)NCCOCCNC(=O)C1=Cc2ccccc2S1(=O)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Medellin B, et al. Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells. J Med Chem. 2022;65(1):507-519.?

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