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SC-68448
CAS No. 188804-07-1
SC-68448( SC68448 )
Catalog No. M12956 CAS No. 188804-07-1
SC-68448 (SC68448) is a potent, selective peptidomimetic antagonist of the integrin αvβ3 with IC50 of 1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NameSC-68448
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NoteResearch use only, not for human use.
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Brief DescriptionSC-68448 (SC68448) is a potent, selective peptidomimetic antagonist of the integrin αvβ3 with IC50 of 1 nM.
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DescriptionSC-68448 (SC68448) is a potent, selective peptidomimetic antagonist of the integrin αvβ3 with IC50 of 1 nM, 100-fold selectivity over αIIbβ3; inhibits alpha(v)beta3-mediated endothelial cell proliferation in a dose-dependent manner but did not inhibit tumor cell proliferation in cell-based assays; inhibits angiogenesis in vivo in a basic fibroblast growth factor-induced rat corneal neovascularization model.
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In Vitro——
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In Vivo——
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SynonymsSC68448
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PathwayCell Cycle/DNA Damage
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TargetIntegrin
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RecptorIntegrin
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Research Area——
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Indication——
Chemical Information
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CAS Number188804-07-1
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Formula Weight452.292
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Molecular FormulaC19H19Cl2N5O4
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameBenzenepropanoic acid, beta-[[2-[[3-[(aminoiminomethyl)amino]benzoyl]amino]acetyl]amino]-3,5-dichloro-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Carron CP, et al. Cancer Res. 1998 May 1;58(9):1930-5.
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